Hecate and Ethan struggle to survive the harsh wasteland of the New Mexico desert. Kaetenay reveals to Sir Malcolm the truth behind his connection to Ethan. Back in London, Frankenstein's addition to Jekyll's formula is a success.
- Josh Hartnett as Ethan Chandler
- Timothy Dalton as Sir Malcolm Murray
- Harry Treadaway as Victor Frankenstein
- Wes Studi as Kaetenay
- Sarah Greene as Hecate Poole
- Douglas Hodge as Bartholomew Rusk
- Shazad Latif as Dr. Henry Jekyll
- Sean Gilder as Marshal Franklin Ostow
- Brian Cox as Jared Talbot
- Jack Hickey as Junior Inspector
- Jamie Ballard as Balfour
- Brendan Gibson as Rance
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